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Additionally, the formation and deposition of advanced glycation end products (AGEs) are accelerated during DM, which have been shown to promote the generation of ROS to induce mesangial cell apoptosis, thereby playing a crucial role in the pathogenesis of DN [116] (Fig

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Smoking bombards your entire body with a long list of harmful chemicals including carbon monoxide, cyanide, tar, and formaldehyde the impact of which starves your body of oxygen, vitamins and nutrients